Stand Up To Cancer (SU2C) is a charitable program of the Entertainment Industry Foundation (EIF) established by media, entertainment and philanthropic leaders who have been affected by cancer. Raising awareness and bringing about an understanding that everyone is connected by cancer, SU2C raised a record $100 million for translational cancer research through online and televised efforts. For the Big Three television networks — NBC, CBS and ABC — it was an event they had never done anything like before. On Friday, Sept. 5th, their news anchors — Brian Williams, Katie Couric and Charles Gibson, respectively — sat on one set for a commercial-free, prime-time simulcast entitled “Stand Up to Cancer.” The extraordinary broadcast was for a cause that the networks believe worthy of such an unprecedented collaboration — the fight against cancer. It was also Couric’s first live appearance on TODAY, the show she co-anchored for 15 years, since taking over as the CBS Evening News anchor two years earlier. At the event, Christina Applegate wore Alex Woo's Open Heart Necklace and Little Letter Question Mark. She has founded Right Action for Women, a foundation to aid those individuals who are at increased risk for breast cancer and do not have insurance or the financial flexibility to cover the high costs associated with breast screenings.